Metabolic Messengers: glucagon.
Patrick E MacDonaldPatrik RorsmanPublished in: Nature metabolism (2023)
Plasma glucose is tightly regulated via the secretion of the two glucose-regulating hormones insulin and glucagon. Situated next to the insulin-secreting β-cells, the α-cells produce and secrete glucagon-one of the body's few blood glucose-increasing hormones. Diabetes is a bihormonal disorder, resulting from both inadequate insulin secretion and dysregulation of glucagon. The year 2023 marks the 100th anniversary of the discovery of glucagon, making it particularly timely to highlight the roles of this systemic metabolic messenger in health and disease.
Keyphrases
- blood glucose
- glycemic control
- type diabetes
- induced apoptosis
- cell cycle arrest
- cardiovascular disease
- public health
- mental health
- blood pressure
- small molecule
- transcription factor
- adipose tissue
- cell death
- insulin resistance
- metabolic syndrome
- risk assessment
- health information
- climate change
- human health
- social media
- single cell