GDF-15 is associated with sarcopenia and frailty in acutely admitted older medical patients.

Rikke S KamperHanne NygaardLouis Praeger-JahnsenAnette EkmannSisse Bolm DitlevMartin SchultzSofie Krarup HansenPernille HansenEckart PresselCharlotte Suetta

Published in: Journal of cachexia, sarcopenia and muscle (2024)

Systemic GDF-15 was higher in acutely admitted older medical patients with sarcopenia and frailty compared with patients without. The present study defined the optimum cut-off for GDF-15, related to the presence of sarcopenia and frailty, respectively. When elevated above the derived cutoffs, GDF-15 was strongly associated with frailty and sarcopenia in both crude and fully adjusted models.

Keyphrases

community dwelling
end stage renal disease
newly diagnosed
ejection fraction
skeletal muscle
healthcare
chronic kidney disease
prognostic factors
patient reported outcomes
middle aged