Combined analysis of gut microbiota, diet and PNPLA3 polymorphism in biopsy-proven non-alcoholic fatty liver disease.

Sonja LangAnna MartinXinlian ZhangFedja FarowskiHilmar WisplinghoffMaria J G T VehreschildMarcin KrawczykAngela NowagAnne KretzschmarClaus ScholzPhilipp KasperChristoph RoderburgRaphael MohrFrank LammertFrank TackeBernd SchnablTobias GoeserHans-Michael SteffenMünevver Demir

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

BMI had the strongest association with histological fibrosis, but PNPLA3 gene variants, gut bacterial features and dietary factors were all associated with different histology features, which underscore the multifactorial pathogenesis of NAFLD.

Keyphrases

copy number
body mass index
liver fibrosis
physical activity
weight loss
ultrasound guided
fine needle aspiration
weight gain
transcription factor