Intestinal tuberculosis presented as spindle cell pseudotumor in a HIV-positive case.
Chengbo LiQingfu ZhangYing WenPublished in: Revista espanola de enfermedades digestivas (2023)
MSP is a rare and atypical form of benign granulomatous inflammation characterised by tumour-like local proliferation of spindle-shaped histiocytes containing acid-fast positive mycobacteria, which should be differentiated from neoplastic lesions. A 26-year-old Chinese man complained an intermittent and mild right lower abdominal pain for 5 months in May 2022.Histopathology of biopsy samples showed Mycobacterial spindle cell pseudotumor (MSP). The test of Mycobacterium tuberculosis detected by polymerase chain reaction using intestinal tissue slice was negative. The metagenomic next-generation sequencing (BGI-Shenzhen) using formalin-fixation and paraffin-embedded intestine samples confirmed Mycobacterium tuberculosis complex (MTBC).
Keyphrases
- mycobacterium tuberculosis
- hiv positive
- pulmonary tuberculosis
- abdominal pain
- single cell
- men who have sex with men
- cell therapy
- south africa
- antiretroviral therapy
- oxidative stress
- signaling pathway
- minimally invasive
- stem cells
- high intensity
- computed tomography
- emergency department
- hepatitis c virus
- genome wide
- circulating tumor
- antibiotic resistance genes
- circulating tumor cells