Pharmacokinetics of ginkgolide B-lyophilized nanoparticles after intravenous injection in rats using liquid chromatography-tandem mass spectrometry.

Lisha MaLujia ZhuJianan PengShujun XuYue ZhaoJingbin ShiQi LiuHui ZhangJun LiYang Xiong

Published in: Rapid communications in mass spectrometry : RCM (2023)

A rapid and accurate LC-MS/MS method was established for the determination of GB-NPs in rats. GB-NPs exhibited a sustained-release behavior in vivo compared with GB solution.

Keyphrases

liquid chromatography tandem mass spectrometry
solid phase extraction
simultaneous determination
ms ms
molecularly imprinted
high resolution
oxide nanoparticles
ultrasound guided
low dose
mass spectrometry