Polymerized Tannic Acid Offers a Nanosized Platform to Combat Bacterial Infection.

Worldwide antibiotic abuse accelerates the evolution of drug-resistant super bacteria, which goes against the war toward bacterial infection. Antibiotic-loaded nanoparticles as a typical form of nanomedicine hold great promise in combating bacterial infection, which requires the development of a suitable carrier. Tannic acid (TA) showed an inhibition effect on both Gram-positive and -negative strains; however, there are no reports on the development of antibacterial nanoformulations based on TA itself. We could get PTA NPs using a one-pot method, and their size and ζ-potential were characterized. Herein, we carefully tuned the polymerization of TA to give well-dispersed polytannic acid nanoparticles (PTA NPs) with a size of 100 nm. Moreover, our results demonstrated that PTA NPs showed enhanced antibacterial effects on both Gram-positive and -negative strains as compared to free TA. Especially, PTA NPs can preferably accelerate the healing of <i>Staphylococcus</i>-infected wounds. Based on its structure, we suggested that PTA NPs may have a similar property to polydopamine nanoparticles to offer high drug loading for potential combination therapy for extended application in bacterial infection management.