Chrysin Inhibits High Glucose-Induced Migration on Chorioretinal Endothelial Cells via VEGF and VEGFR Down-Regulation.

Zhen-Yu LiaoI-Chia LiangHsin-Ju LiChia-Chun WuHuey-Ming LoDer-Chen ChangChi-Feng Hung

Published in: International journal of molecular sciences (2020)

The results indicate that chrysin could down-regulate the phosphorylation of AKT, ERK and MMP-2 and reduce the effects of VEGF and VEGFR in a high glucose environment. It further inhibits the high glucose-induced migration of RE/6A cells. Therefore, chrysin may have the potential for visual protection.

Keyphrases

high glucose
endothelial cells
vascular endothelial growth factor
signaling pathway
induced apoptosis
cell proliferation
risk assessment
cell cycle arrest
climate change
cell migration
protein kinase