Cerebral hemodynamics during atrial fibrillation: Computational fluid dynamics analysis of lenticulostriate arteries using 7 T high-resolution magnetic resonance imaging.
Stefania ScarsoglioAndrea SagliettoF TripoliJaco J M ZwanenburgGeert Jan BiesselsGaetano Maria De FerrariMatteo AnselminoLuca RidolfiPublished in: Physics of fluids (Woodbury, N.Y. : 1994) (2022)
Atrial fibrillation (AF) is the most common cardiac arrhythmia, inducing irregular and faster heart beating. Aside from disabling symptoms-such as palpitations, chest discomfort, and reduced exercise capacity-there is growing evidence that AF increases the risk of dementia and cognitive decline, even in the absence of clinical strokes. Among the possible mechanisms, the alteration of deep cerebral hemodynamics during AF is one of the most fascinating and least investigated hypotheses. Lenticulostriate arteries (LSAs)-small perforating arteries perpendicularly departing from the anterior and middle cerebral arteries and supplying blood flow to basal ganglia-are especially involved in silent strokes and cerebral small vessel diseases, which are considered among the main vascular drivers of dementia. We propose for the first time a computational fluid dynamics analysis to investigate the AF effects on the LSAs hemodynamics by using 7 T high-resolution magnetic resonance imaging (MRI). We explored different heart rates (HRs)-from 50 to 130 bpm-in sinus rhythm and AF, exploiting MRI data from a healthy young male and internal carotid artery data from validated 0D cardiovascular-cerebral modeling as inflow condition. Our results reveal that AF induces a marked reduction of wall shear stress and flow velocity fields. This study suggests that AF at higher HR leads to a more hazardous hemodynamic scenario by increasing the atheromatosis and thrombogenesis risks in the LSAs region.
Keyphrases
- atrial fibrillation
- blood flow
- magnetic resonance imaging
- catheter ablation
- oral anticoagulants
- cognitive decline
- left atrial
- subarachnoid hemorrhage
- mild cognitive impairment
- high resolution
- left atrial appendage
- direct oral anticoagulants
- internal carotid artery
- heart failure
- contrast enhanced
- cerebral ischemia
- percutaneous coronary intervention
- computed tomography
- electronic health record
- cognitive impairment
- middle cerebral artery
- magnetic resonance
- dna methylation
- physical activity
- mass spectrometry
- risk assessment
- genome wide
- heart rate
- body composition
- atomic force microscopy
- tandem mass spectrometry
- data analysis