Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies.
Mika KivimakiKeenan A WalkerJaana PenttiSolja T NybergNina MarsJussi VahteraSakari B SuominenTea LallukkaOssi RahkonenOlli PietiläinenAki KoskinenAri VäänänenJatinderpal K KalsiMarcel GoldbergMarie ZinsLars AlfredssonPeter J M WesterholmAnders KnutssonTöres TheorellJenni ErvastiTuula OksanenPyry N SipiläAdam G TabakJane E FerrieStephen A WilliamsGill LivingstonRebecca F GottesmanArchana Singh-ManouxHenrik ZetterbergJoni V LindbohmPublished in: BMJ (Clinical research ed.) (2021)
The risk of dementia in old age was found to be lower in people with cognitively stimulating jobs than in those with non-stimulating jobs. The findings that cognitive stimulation is associated with lower levels of plasma proteins that potentially inhibit axonogenesis and synaptogenesis and increase the risk of dementia might provide clues to underlying biological mechanisms.