Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.

Cecilia AnsaloneRichard I AinsworthGyrid NygaardRizi AiEdward B PrideauxDeepa HammakerNarayanan B PerumalKen WeichertFrances TungLalitha KodandapaniJ Michael SauderElisabeth C MertschingRobert J BenschopDavid L BoyleWei WangGary S Firestein

Published in: ACR open rheumatology (2021)

Blocking caspase-8 variant G could decrease cell invasion in diseases like RA without the potential deleterious effects of nonspecific caspase-8 inhibition.

Keyphrases

rheumatoid arthritis
cell death
induced apoptosis
disease activity
ankylosing spondylitis
interstitial lung disease
signaling pathway
oxidative stress
human health
risk assessment
climate change
wound healing