Quantitative and Qualitative Changes in Peripheral Chemoreceptor Activity in Preterm Infants.
Daniel M MammelJohn L CarrollBarbara B WarnerBradley A EdwardsDwayne L MannMichael J WallendorfJulie A HoffmannCameron M ConklinHarley PylesJames S KempPublished in: American journal of respiratory and critical care medicine (2022)
Among preterm infants, the peripheral chemoreceptor contribution to ventilatory drive was greater at earlier postmenstrual ages. Apnea was a frequent response to hyperoxic testing at earlier postmenstrual ages, suggesting high peripheral chemoreceptor activity. A clearer description of how peripheral chemoreceptor activity changes over time in preterm infants may help explain how ventilatory control instability contributes to apnea and sleep-disordered breathing later in childhood.