AuNP Coupled Rapid Flow-Through Dot-Blot Immuno-Assay for Enhanced Detection of SARS-CoV-2 Specific Nucleocapsid and Receptor Binding Domain IgG.

Bijon Kumar Sil Mohd Raeed Jamiruddin Md Ahsanul Haq Mohib Ullah Khondoker Nowshin Jahan Shahad Saif Khandker Nor Azlina A Ali Mumtarin Jannat Oishee Taku Kaitsuka Masayasu Mie Kazuhito Tomizawa Eiry Kobatake Mainul Haque Nihad Adnan

Published in: International journal of nanomedicine (2021)

The assay can confirm past SARS-CoV-2 infection with high accuracy within 2 minutes compared to commercial CLIA or in-house ELISA. It can help track SARS-CoV-2 disease progression, population screening, and vaccination response. The ease of use of the assay without requiring any instruments while being semi-quantitative provides the avenue of its implementation in remote areas around the globe, where conventional serodiagnosis is not feasible.

Keyphrases

sars cov
respiratory syndrome coronavirus
high throughput
loop mediated isothermal amplification
primary care
healthcare
coronavirus disease
high resolution
quality improvement
transcription factor
patient reported outcomes
monoclonal antibody