A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions.
Bread CruzAndré OliveiraGislaine VentrucciMaria Cristina Cintra Gomes-MardondesPublished in: BMC cancer (2019)
Meanwhile, the leucine-rich diet modulated key steps of the mTOR pathway by triggering the increased activation of RAG and mTOR and maintaining JNK, STAT-3 and STAT-6 levels in muscle, leading to an increased muscle protein synthesis, reducing the degradation during tumour evolution in a host, minimising the cancer-induced damages in the cachectic state.
Keyphrases
- cell proliferation
- skeletal muscle
- physical activity
- weight loss
- papillary thyroid
- single cell
- high glucose
- signaling pathway
- cell death
- stem cells
- diabetic rats
- young adults
- cell therapy
- oxidative stress
- induced apoptosis
- squamous cell carcinoma
- endothelial cells
- squamous cell
- lymph node metastasis
- childhood cancer
- stress induced