Long-Term Mortality in Patients With Severe Hypercholesterolemia Phenotype From a Racial and Ethnically Diverse US Cohort.
Jeremy A MilesAndrea ScottiFrancesco CastagnaToshiki KunoPier Pasquale LeoneAugustin CoisneSebastian LudwigCarl J LavieParag H JoshiAzeem LatibMario J GarciaCarlos J RodriguezMichael David ShapiroSalim S ViraniLeandro SlipczukPublished in: Circulation (2023)
In a large, diverse cohort of US patients with the severe hypercholesterolemia phenotype, we identified several patient characteristics associated with increased 9-year all-cause mortality and observed a decrease in statin use over time, in particular for primary prevention. Our results support efforts geared toward early recognition and consistent treatment for patients with severe hypercholesterolemia.