Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice.
Tetsuya KounoSuling ZengYanhan WangYi DuanSonja LangBei GaoPhillipp HartmannNoemí CabréCristina LlorenteChloé GalbertPatrick EmondHarry SokolMichael JamesChun Cheih ChaoJian-Rong GaoMylene PerreaultDavid L HavaBernd SchnablPublished in: Alcoholism, clinical and experimental research (2023)
Our findings indicate that tryptophan metabolites locally produced by engineered gut bacteria mitigate liver disease via Ahr-mediated activation in intestinal immune cells.