Pharmacokinetics in Morbid Obesity: Influence of Two Bariatric Surgery Techniques on Paracetamol and Caffeine Metabolism.

Albert Goday ArnoMagí FarréJose Rodríguez-MoratóJose M RamonClara Pérez-MañáEsther PapaseitEster CivitKlaus LangohrMarcel Lí CarbóDavid Benaiges BoixOlga Castañer NinoJuana Antonia Flores Le RouxManuel PeraLuis GrandeRafael de la Torre

Published in: Obesity surgery (2018)

Paracetamol pharmacokinetics and caffeine plasma levels are altered in severely obese patients. The two studied bariatric surgical techniques normalize paracetamol oral bioavailability without impairing the liver function (measured by cytochrome P450 1A2 activity).

Keyphrases

bariatric surgery
obese patients
weight loss
roux en y gastric bypass
gastric bypass
anti inflammatory drugs
insulin resistance
type diabetes
metabolic syndrome
adipose tissue
physical activity