Whole Blood Transcriptional Fingerprints of High-Grade Glioma and Longitudinal Tumor Evolution under Carbon Ion Radiotherapy.
Maximilian KnollMaria WaltenbergerJennifer FurkelUte WirknerAoife Ward GahlawatIvana DokicChristian SchwagerSebastian AdebergStefan RiekenTobias KesslerFelix SahmLaila KönigChristel Herold-MendeStephanie E CombsJürgen DebusAmir AbdollahiPublished in: Cancers (2022)
Lbx based WTB analysis holds the potential for molecular stratification of rHGG patients and therapy monitoring. We demonstrate the feasibility of the peripheral blood transcriptome as a sentinel organ for identification of patient, tumor characteristics and CIR specific fingerprints in rHGG.
Keyphrases
- high grade
- peripheral blood
- end stage renal disease
- gene expression
- ejection fraction
- newly diagnosed
- chronic kidney disease
- early stage
- peritoneal dialysis
- prognostic factors
- radiation therapy
- single cell
- case report
- transcription factor
- squamous cell carcinoma
- genome wide
- rna seq
- single molecule
- heat shock
- human health
- risk assessment
- bone marrow
- smoking cessation
- replacement therapy