TNF reduces osteogenic cell fate in PDL cells at transcriptional and functional levels without alteration of periodontal proliferative capacity.

Isabel KnaupRafael KramannMartha-Julia SasulaPaula MackRogério Bastos CraveiroChristian NiederauFranziska CoenenSabine NeussJoachim JankowskiMichael Wolf

Published in: Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie (2024)

The present data confirm TNF as a regulatory factor of proinflammatory remodeling that influences the differentiation behavior but not the metabolism and cell proliferation of the periodontium. Therefore, TNF represents an interesting target for the regulation of orthodontic remodeling processes in the periodontium.

Keyphrases

rheumatoid arthritis
cell fate
cell proliferation
induced apoptosis
transcription factor
mesenchymal stem cells
bone marrow
gene expression
cell cycle arrest
electronic health record
machine learning
pi k akt
endoplasmic reticulum stress
signaling pathway
data analysis