A new strategy for stem cells therapy for erectile dysfunction: Adipose-derived stem cells transfect Neuregulin-1 gene through superparamagnetic iron oxide nanoparticles.

Jianxing Cheng Zhongjie Zheng Wenhao Tang Jichun Shao Jiang Hui Hao-Cheng Lin

Published in: Investigative and clinical urology (2022)

PEI-SPION can be used as a vector for NRG1 gene transfection into ADSCs. PEI-SPION-NRG1-PEI packaging has the highest transfection efficiency under the external magnetic field than the other groups. These findings may provide a new strategy for ADSCs therapy for ED.

Keyphrases

iron oxide nanoparticles
stem cells
copy number
genome wide
emergency department
genome wide identification
gene expression
dna methylation
transcription factor
bone marrow