Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations.

Catherine LalandeJean-Philippe Drouin-ChartierAndré J TremblayPatrick CoutureAlain Veilleux

Published in: Diabetology & metabolic syndrome (2020)

Our study supports a decreased functional enterocyte mass and an increased enterocyte death rate in presence of metabolic alterations but emphasizes that epithelial cell homeostasis is especially altered in presence of severe insulin resistance and T2D. The marked changes in small intestine cellularity observed in obesity and diabetes are thus suggested to be part of gut dysfunctions, mainly at an advanced stage of the disease.

Keyphrases

insulin resistance
type diabetes
high fat diet induced
metabolic syndrome
adipose tissue
high fat diet
weight loss
skeletal muscle
glycemic control
polycystic ovary syndrome
cardiovascular disease
weight gain
early onset
drug induced