Anti-inflammatory and Proapoptotic Properties of the Natural Compound o-Orsellinaldehyde.
Sarah Tomas-HernandezSantiago Garcia-VallvéGerard PujadasCristina VallsMaría José Ojeda-MontesAleix GimenoAdrià Cereto-MassaguéJoel Roca-MartinezManuel SuárezLluis ArolaJordi BlancoMiquel MuleroRaúl Beltran-DebónPublished in: Journal of agricultural and food chemistry (2018)
Metabolic syndrome is a cluster of medical conditions that increases the risk of developing cardiovascular disease and type 2 diabetes. Numerous studies have shown that inflammation is directly involved in the onset of metabolic syndrome and related pathologies. In this study, in silico techniques were applied to a natural products database containing molecules isolated from mushrooms from the Catalan forests to predict molecules that can act as human nuclear-factor κβ kinase 2 (IKK-2) inhibitors. IKK-2 is the main component responsible for activating the nuclear-factor κβ transcription factor (NF-κβ). One of these predicted molecules was o-orsellinaldehyde, a molecule present in the mushroom Grifola frondosa. This study shows that o-orsellinaldehyde presents anti-inflammatory and pro-apoptotic properties by acting as IKK-2 inhibitor. Additionally, we suggest that the anti-inflammatory and pro-apoptotic properties of Grifola frondosa mushroom could partially be explained by the presence of o-orsellinaldehyde on its composition.
Keyphrases
- anti inflammatory
- nuclear factor
- metabolic syndrome
- toll like receptor
- cardiovascular disease
- type diabetes
- transcription factor
- signaling pathway
- cell death
- endothelial cells
- oxidative stress
- insulin resistance
- healthcare
- climate change
- cardiovascular risk factors
- inflammatory response
- immune response
- molecular docking
- tyrosine kinase
- drug induced
- glycemic control
- coronary artery disease
- protein kinase
- pi k akt
- skeletal muscle
- weight loss
- adverse drug