Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer.
Majid AliporPublished in: Journal of gastrointestinal cancer (2020)
The bacterium has various virulence factors, including cytotoxin- associated gene A, vacuolating cytotoxin A, and the different outer membrane proteins that cause cancer by different mechanisms. These virulence factors activate cell signaling pathways such as PI3-kinase/Akt, JAK/STAT and Ras, Raf, and ERK signaling that control cell proliferation. Uncontrolled proliferation can lead to cancer.
Keyphrases
- helicobacter pylori
- signaling pathway
- cell proliferation
- papillary thyroid
- pi k akt
- escherichia coli
- pseudomonas aeruginosa
- staphylococcus aureus
- squamous cell
- helicobacter pylori infection
- biofilm formation
- antimicrobial resistance
- cell cycle
- lymph node metastasis
- squamous cell carcinoma
- single cell
- cell therapy
- induced apoptosis
- stem cells
- dna methylation
- copy number
- genome wide
- gene expression
- childhood cancer
- high glucose
- tyrosine kinase
- endothelial cells
- transcription factor