SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2.
Emma BarrosoRosalía Rodríguez-RodríguezMohammad ZareiJavier Pizarro-DegadoAnna PlanavilaXavier PalomerFrancesc VillarroyaManuel Vázquez-CarreraPublished in: Cell communication and signaling : CCS (2020)
These findings demonstrate new mechanisms by which Sirt3 deficiency contributes to hepatic steatosis. Video abstract.