Histomorphometric analysis of implant osseointegration using hydrophilic implants in diabetic rats.
Alessandra Julie SchusterJoão Luiz Bittencourt de AbreuNatalia Marcumini PolaLukasz WitekPaulo G CoelhoFernanda FaotPublished in: Clinical oral investigations (2021)
The adverse effects of diabetes mellitus with respect to bone healing may be minimized by deploying implants with strategically modified surfaces. This study evaluated the effects of implants with Acqua® and Neoporos® surfaces in both diabetic and healthy animals. During the initial healing period in diabetic animals, the hydrophilic surface was demonstrated to have beneficial effect on osseointegration in comparison to the hydrophobic surface. The results provide an insight into early healing, but the authors suggest that a future short-term and long-term clinical study is needed to assess the possible benefit of the Acqua® implant as well as in increasing the predictability of implant osseointegration.
Keyphrases
- soft tissue
- diabetic rats
- type diabetes
- liquid chromatography
- oxidative stress
- biofilm formation
- wound healing
- solid phase extraction
- ionic liquid
- adipose tissue
- bone mineral density
- emergency department
- escherichia coli
- insulin resistance
- staphylococcus aureus
- postmenopausal women
- skeletal muscle
- pseudomonas aeruginosa
- simultaneous determination
- glycemic control
- tandem mass spectrometry
- drug induced
- clinical evaluation