Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate.
Shui-Mei ZhangKun HuXiao-Nian LiHan-Dong SunPema-Tenzin PunoPublished in: Natural products and bioprospecting (2022)
A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7-13) were isolated from the stems of Schisandra bicolor var. tuberculate. The structures of 1-4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- molecular dynamics
- signaling pathway
- high resolution
- oxidative stress
- molecular docking
- density functional theory
- molecular dynamics simulations
- electronic health record
- high intensity
- computed tomography
- monte carlo
- mass spectrometry
- dual energy
- crystal structure
- artificial intelligence
- energy transfer
- data analysis