Image Analysis of Eosinophil Peroxidase Immunohistochemistry for Diagnosis of Eosinophilic Esophagitis.

Benjamin L WrightAlfred D DoyleKelly P ShimRish K PaiSuzanne M BarshowJennifer L Horsley-SilvaHuijun LuoMatthew A RankElizabeth A JacobsenDavid A KatzkaHirohito KitaEvan S Dellon

Published in: Digestive diseases and sciences (2020)

EPX/mm2 correlates strongly with eos/hpf, accurately identifies subjects with EoE, and decreases in treatment responders. Automated quantification of intact eosinophils and their degranulation products may enhance pathologic assessment. Future studies are needed to correlate EPX/mm2 with symptoms, endoscopic findings, and esophageal distensibility.

Keyphrases

machine learning
neoadjuvant chemotherapy
ultrasound guided
deep learning
squamous cell carcinoma
current status
gene expression
radiation therapy
chronic rhinosinusitis
combination therapy
case control
lymph node
single cell