Copper(II)-Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of Indoles with Isatin-Derived N -Boc-Ketimines.

Leipeng XueJiaqi HouJiahui LiTianxu YuQihang CaiShibo YuChao YaoYue-Ming Li

Published in: The Journal of organic chemistry (2023)

The copper(II)-catalyzed enantioselective aza-Friedel-Crafts reaction of indoles with isatin-derived N -Boc-ketimines was developed by using tunable chiral O-N-N tridentate ligands derived from BINOL and proline. In general, the reaction afforded chiral 3-indolyl-3-aminooxindoles under mild conditions in high yields (83-97%) with excellent ee (69-99%).

Keyphrases

room temperature
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