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Visible-Light-Induced PhI(OAc) 2 -Mediated Alkylation of Heteroarenes with Simple Alkanes and Ethers.

Lusina MantryParthasarathy Gandeepan
Published in: The Journal of organic chemistry (2024)
The direct alkylation of heteroarenes with alkanes has been successfully achieved through visible-light-induced hypervalent iodine-mediated C-H functionalization of both coupling partners at ambient temperatures. This reaction proceeds via the in situ generation of nucleophilic alkyl radicals from alkanes through hydrogen atom transfer (HAT), followed by a Minisci-type reaction with heteroarenes. These mild reaction conditions have demonstrated their suitability for the alkylation of a wide range of heterocycles, including azoles, pyridines, quinolines, isoquinolines, and quinoxalinones.
Keyphrases
  • visible light
  • electron transfer
  • air pollution
  • particulate matter
  • high glucose
  • molecular dynamics
  • room temperature
  • computed tomography
  • magnetic resonance imaging
  • magnetic resonance
  • walled carbon nanotubes