Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms.

Xiu LiuJia-Wei GuoXiao-Chun LinYong-Hua TuoWan-Li PengSu-Yue HeZhao-Qiang LiYan-Chen YeJie YuFei-Ran ZhangMing-Ming MaJin-Yan ShangXiao-Fei LvAn-Dong ZhouYing OuyangCheng WangRui-Ping PangJian-Xin SunJing-Song OuJia-Guo ZhouSi-Jia Liang

Published in: European heart journal (2021)

Macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, indicating that the NFATc3/miR-204 axis may be a potential therapeutic target against atherosclerosis.

Keyphrases

cell proliferation
cardiovascular disease
long non coding rna
single cell
cell therapy
adipose tissue
long noncoding rna
stem cells
type diabetes
mesenchymal stem cells
risk assessment