Fenfluramine increases survival and reduces markers of neurodegeneration in a mouse model of Dravet syndrome.
John ChaGregory FilatovSteven J SmithArnold R GammaitoniAmélie LotheThadd ReederPublished in: Epilepsia open (2023)
This is the first report of anti-neuroinflammation and pro-survival after fenfluramine treatment in a mammalian DS model. These results corroborate prior data in humans and animal models and suggest important pharmacological activities for fenfluramine beyond seizure reduction.