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Fenfluramine increases survival and reduces markers of neurodegeneration in a mouse model of Dravet syndrome.

John ChaGregory FilatovSteven J SmithArnold R GammaitoniAmélie LotheThadd Reeder
Published in: Epilepsia open (2023)
This is the first report of anti-neuroinflammation and pro-survival after fenfluramine treatment in a mammalian DS model. These results corroborate prior data in humans and animal models and suggest important pharmacological activities for fenfluramine beyond seizure reduction.
Keyphrases
  • mouse model
  • traumatic brain injury
  • lipopolysaccharide induced
  • case report
  • cognitive impairment
  • big data
  • lps induced
  • free survival
  • artificial intelligence