Orlistat and metformin combination ameliorates obesity-induced renal injury via suppressing renal oxidative stress in male rats.
Khadeejah AlsolamiReham Z HamzaPublished in: Toxicology research (2024)
The data displayed that the combination of both ORS and MEF declined the obesity effects significantly by reducing the level of peroxidation (MDA), and enhancement intracellular antioxidant enzymes. These biochemical findings were supported by histopathology, immunohistochemistry, and Masson-Trichrome evaluation, which showed minor morphological changes in the kidneys of rats.
Keyphrases
- oxidative stress
- insulin resistance
- diabetic rats
- weight loss
- metabolic syndrome
- high fat diet induced
- type diabetes
- weight gain
- high glucose
- dna damage
- signaling pathway
- electronic health record
- ischemia reperfusion injury
- adipose tissue
- breast cancer cells
- anti inflammatory
- skeletal muscle
- reactive oxygen species
- machine learning
- data analysis
- cell death
- pi k akt