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Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation invitro after abbreviated gonadotropin stimulation.

Sabrina PiechotaMaria MarchanteAlexa GiovanniniBruna PaulsenKathryn S PottsGraham RockwellCaroline AschenbergerAlexander D NoblettAlexandra B FigueroaMarta SanchezFerran BarrachinaKlaus WiemerLuis GuzmanPedro BelchinMerrick Pierson SmelaPatrick R J FortunaPranam ChatterjeeNam D TranDawn A KelkMarcy FortiShelby MarcinyshynTrozalla SmithDavid H McCullohMarta-Julia Fernandez-GonzalezBaruch AbittanSilvia OrtizJoshua U KleinPeter KlatskyDaniel Ordonez-PerezChristian C Kramme
Published in: Human reproduction (Oxford, England) (2023)
A.D.N., A.B.F., A.G., B.P., C.A., C.C.K., F.B., G.R., K.S.P., K.W., M.M., P.C., S.P., and M.-J.F.-G. are shareholders in the for-profit biotechnology company Gameto Inc. P.R.J.F. declares paid consultancy for Gameto Inc. P.C. also declares paid consultancy for the Scientific Advisory Board for Gameto Inc. D.H.M. has received consulting services from Granata Bio, Sanford Fertility and Reproductive Medicine, Gameto, and Buffalo IVF, and travel support from the Upper Egypt Assisted Reproduction Society. C.C.K., S.P., M.M., A.G., B.P., K.S.P., G.R., and A.D.N. are listed on a patent covering the use of OSCs for IVM: U.S. Provisional Patent Application No. 63/492,210. Additionally, C.C.K. and K.W. are listed on three patents covering the use of OSCs for IVM: U.S. Patent Application No. 17/846,725, U.S Patent Application No. 17/846,845, and International Patent Application No.: PCT/US2023/026012. C.C.K., M.P.S., and P.C. additionally are listed on three patents for the transcription factor-directed production of granulosa-like cells from stem cells: International Patent Application No.: PCT/US2023/065140, U.S. Provisional Application No. 63/326,640, and U.S. Provisional Application No. 63/444,108. The remaining authors have no conflicts of interest to declare.
Keyphrases
  • stem cells
  • transcription factor
  • primary care
  • healthcare
  • type diabetes
  • cell therapy
  • single cell
  • oxidative stress
  • skeletal muscle
  • pregnant women
  • young adults
  • insulin resistance
  • bone marrow