L. pneumophila Infection Diagnosed by tNGS in a Lady with Lymphadenopathy.
Shiying LiJin TongHu LiChenxue MaoWei ShenYu LeiPeng HuPublished in: Infection and drug resistance (2023)
We report a case of a 34-year-old lady with multiple joint pain. Autoimmune diseases were considered first with a positive result of anti-Ro antibody and her right knee joint cavity effusion. Later, bilateral interstitial changes in her lungs and mediastinal lymphadenopathy were found after chest CT scanning. Empirical quinolone therapy was given although pathological examinations of blood, sputum and bronchoalveolar lavage fluid (BALF) did not find anything. Finally, Legionella pneumophila was identified by target next-generation sequencing (tNGS) detection. This case highlighted the timely use of tNGS, a new tool with fast speed, high accuracy and effective cost, could help to identify atypical infection and start an early therapy.
Keyphrases
- chronic pain
- cystic fibrosis
- mycobacterium tuberculosis
- computed tomography
- high resolution
- pain management
- fine needle aspiration
- image quality
- pulmonary tuberculosis
- mass spectrometry
- spinal cord injury
- contrast enhanced
- mesenchymal stem cells
- positron emission tomography
- pet ct
- electron microscopy
- real time pcr
- postoperative pain