Iron-Catalyzed, Directed Benzylic Borylation.

Hanbin LeeTiancheng HeSilas P Cook

Published in: Organic letters (2022)

Herein, we describe an iron-catalyzed benzylic C-H borylation reaction. The reaction targets primary and secondary C(sp 3 )-H bonds to deliver high-value boronic esters under mild conditions with short (7-8 min) reaction times. Functional groups are well tolerated, and complete site selectivity is observed in the presence of multiple benzylic C-H bonds.

Keyphrases

room temperature
iron deficiency
electron transfer
structural basis