Detecting time-varying genetic effects in Alzheimer's disease using a longitudinal genome-wide association studies model.

Xiaowei ZhuangGang XuAmei AmeiDietmar CordesZuoheng WangEdwin C Ohnull null

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)

Identify time-varying genetic effects using a longitudinal GWAS model in AD.Illustrate age-dependent genetic effects on both diagnoses and amyloid accumulation.Replicate time-varying effect of APOE in a second dataset.

Keyphrases

genome wide
genome wide association
cognitive decline
copy number
type diabetes
gene expression
adipose tissue
skeletal muscle
mild cognitive impairment
insulin resistance