Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease.

Pierre LavilleSandrine FartekNatacha CerisierDelphine FlattersMichel PetitjeanLeslie Regad

Published in: BMC molecular and cell biology (2020)

This work consists of a structural analysis of the impact of a large number of PR2 resistant mutants based on modeled structures. It suggests three possible resistance mechanisms of PR2, in which structural changes induced by resistance mutations lead to modifications in the dimerization interface, ligand recognition or inhibitor binding.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hepatitis c virus
hiv testing
hiv aids
high resolution
binding protein
mass spectrometry
south africa