Cerebrospinal fluid soluble CD27 is a sensitive biomarker of inflammation in autoimmune encephalitis.

Stefan CobanovicMorten BlaabjergZsolt IllesMette Scheller NissenClaus Henrik NielsenDaniel KondziellaSophie BuheltMie Reith MahlerFinn SellebjergJeppe Romme Christensen

Published in: Journal of the neurological sciences (2024)

CSF sCD27 is a suitable biomarker of neuroinflammation in AE with an ability to discriminate patients with NMDA AE and LGI1 AE from symptomatic controls. CSF sCD27 may be suited for ruling out AE and other neuroinflammatory conditions in the early phase of the diagnostic work-up.

Keyphrases

cerebrospinal fluid
oxidative stress
traumatic brain injury
multiple sclerosis
lps induced
blood brain barrier