Shared genetic influences on depression and menopause symptoms.

Joeri J MeijsenHanyang ShenMytilee VemuriNatalie L RasgonKarestan C KoenenLaramie E Duncan

Published in: Psychological medicine (2021)

These results suggest that menopause symptoms have a complex genetic etiology which is partially shared with genetic influences on depression. Moreover, the TACR3 gene identified here has direct clinical relevance; antagonists for the neurokinin 3 receptor (coded for by TACR3) are effective treatments for hot flashes.

Keyphrases

genome wide
sleep quality
copy number
depressive symptoms
postmenopausal women
dna methylation
gene expression
transcription factor