Calcineurin inhibitor effects on kidney electrolyte handling and blood pressure: tacrolimus versus voclosporin.
Kuang-Yu WeiMartijn H van HeugtenWouter H van MegenRichard van VeghelLinda M RehaumeJennifer L CrossJohn J VielHester van WilligenburgPedro Henrique Imenez SilvaA H Jan DanserJeroen H F de BaaijEwout J HoornPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024)
In contrast to tacrolimus, voclosporin does not cause hypercalciuria and hypomagnesemia, but similarly causes hypertension. Our data reveal differences between the distal tubular effects of tacrolimus and voclosporin and provide a pathophysiological basis for the clinically observed differences between the two calcineurin inhibitors.