An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis.

Several systemic and genetic and/or epigenetic factors acting synergistically or additively are associated with MIH, revealing a multifactorial aetiology model. Peri- and postnatal aetiological factors are more likely to increase the odds of causing MIH than prenatal factors.