Detection of hypermethylated genes as markers for cervical screening in women living with HIV.

Wieke W KremerMarjolein Van ZummerenPutri W NoviantiKarin L RichterWina VerlaatPeter Jf SnijdersDaniëlle Am HeidemanRenske Dm SteenbergenGreta DreyerChris J L M Meijer

Published in: Journal of the International AIDS Society (2019)

Hypermethylation analysis of ASCL1 or LHX8 in cervical scrape material of WLHIV detects all cervical carcinomas with an acceptable sensitivity and good specificity for CIN3+ , warranting further exploration of these methylation markers as a stand-alone test for cervical screening in low-resource settings.

Keyphrases

genome wide
dna methylation
gene expression
metabolic syndrome
pregnant women
high grade
adipose tissue
pregnancy outcomes
real time pcr
breast cancer risk