Associations between an integrated component of maternal glycemic regulation in pregnancy and cord blood DNA methylation.
Diana L Juvinao-QuinteroBeckey TrinhPatrice PerronLuigi BouchardSharon Marie LutzMarie-France HivertPublished in: Epigenomics (2021)
Background: Previous studies suggest that fetal programming to hyperglycemia in pregnancy is due to modulation of DNA methylation (DNAm), but they have been limited in their maternal glycemic characterization. Methods: In the Gen3G study, we used a principal component analysis to integrate multiple glucose and insulin values measured during the second trimester oral glucose tolerance test. We investigated associations between principal components and cord blood DNAm levels in an epigenome-wide analysis among 430 mother-child pairs. Results: The first principal component was robustly associated with lower DNAm at cg26974062 (TXNIP; p = 9.9 × 10-9) in cord blood. TXNIP is a well-known DNAm marker for type 2 diabetes in adults. Conclusion: We hypothesize that abnormal glucose metabolism in pregnancy may program dysregulation of TXNIP across the life course.
Keyphrases
- cord blood
- pregnancy outcomes
- type diabetes
- dna methylation
- preterm birth
- nk cells
- glycemic control
- nlrp inflammasome
- pregnant women
- genome wide
- gene expression
- birth weight
- blood glucose
- cardiovascular disease
- insulin resistance
- quality improvement
- mental health
- copy number
- adipose tissue
- metabolic syndrome
- mass spectrometry
- atomic force microscopy
- blood pressure
- case control
- skeletal muscle
- single molecule