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Immune checkpoint inhibitor-induced lichenoid drug eruption-sparing scar burns.

Kelvin TruongCharmaine Vanessa ChamberlinJennifer KimMatteo S CarlinoRaquel Ruiz Araujo
Published in: The Australasian journal of dermatology (2023)
The authors present a striking case of a patient experiencing a lichenoid drug eruption secondary to immunotherapy, curiously sparing scarred skin from past burns. We observed vastly higher amounts of inflammatory lymphoid cells staining for PD-1; 70% in skin with a lichenoid drug reaction and 50% in scarred skin. The lack of a lichenoid reaction at sites of scarred skin may indicate that a basement membrane component may be causative for a lichenoid drug eruption.
Keyphrases
  • wound healing
  • soft tissue
  • drug induced
  • induced apoptosis
  • adverse drug
  • cell proliferation
  • cell cycle arrest
  • signaling pathway
  • minimally invasive
  • stress induced