Limosilactobacillus reuteri RE225 alleviates gout by modulating the TLR4/MyD88/NF-κB inflammatory pathway and the Nrf2/HO-1 oxidative stress pathway, and by regulating gut microbiota.

Yang QinYucong ZhouJiayi XiongChenyang LuJun ZhouXiurong SuJiaojiao Han

Published in: Journal of the science of food and agriculture (2024)

This study provides a theoretical basis for the comprehensive development of Limosilactobacillus reuteri and new ideas for the non-pharmacological treatment of gout. © 2024 Society of Chemical Industry.

Keyphrases

oxidative stress
toll like receptor
signaling pathway
uric acid
pi k akt
diabetic rats
dna damage
ischemia reperfusion injury
induced apoptosis
inflammatory response
immune response
lps induced
mouse model
cell proliferation