Genetic testing in children with Brugada syndrome: results from a large prospective registry.

Luigi Pannone Antonio Bisignani Randy Osei Anaïs Gauthey Antonio Sorgente Pasquale Vergara Cinzia Monaco Domenico Giovanni Della Rocca Alvise Del MonteAntanas StrazdasJoerelle Mojica Maysam Al Housari Vincenzo Miraglia Sahar MouramGaetano PaparellaRobbert Ramak Ingrid OvereinderGezim BalaAlexandre Almorad Erwin Ströker Gudrun PappaertJuan SieiraThomy de RavelMark La Meir Pedro BrugadaGian Battista ChierchiaSonia Van Dooren Carlos De Asmundis

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)

In a large BrS cohort, the diagnostic yield for P/LP variants in the paediatric population is 46%. P+ children with BrS have a worse arrhythmic prognosis.

Keyphrases

young adults
intensive care unit
emergency department
copy number
gene expression
dna methylation