Differences in the mutational landscape of triple-negative breast cancer in African Americans and Caucasians.

Foluso O AdemuyiwaYu TaoJingqin LuoKatherine WeilbaecherCynthia X Ma

Published in: Breast cancer research and treatment (2016)

The mutational landscape of TNBC is similar between African Americans and Caucasians. The higher frequency of TNBC in African Americans is therefore not associated with a different genomic profile of commonly established tumor regulatory pathway genes. Other modifiable factors may exist that contribute to the racial disparity in TNBC.

Keyphrases

single cell
genome wide
transcription factor
copy number
bioinformatics analysis
gene expression
dna methylation