Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder.
Darina CzamaraAlexa NeufangRoman DieterleStella IuratoJanine ArlothJade MartinsMarcus IsingElisabeth E BinderAngelika ErhardtPublished in: Clinical epigenetics (2022)
This first DNAm analysis in PD reveals first evidence of small but significant DNAm changes in PD in association with cumulative stress-weighted life events. Most of the top associated CpG-sites are located in genes implicated in metabolic processes supporting the hypothesis that environmental stress contributes to health damaging changes by affecting a broad spectrum of systems in the body.