The beneficial effect of chronic muscular exercise on muscle fragility is increased by Prox1 gene transfer in dystrophic mdx muscle.
Alexandra MonceauClément DelacroixMégane LemaitreGaelle RevetDenis FurlingOnnik AgbulutArnaud KleinArnaud FerryPublished in: PloS one (2022)
Our results indicate that Prox1 transfer increased the beneficial effect of chronic exercise on muscle fragility in mdx mice, but reduced absolute maximal force. Thus, the potential clinical benefit of the transfer of Prox1 into exercised dystrophic muscle can merit further investigation.