Caveolar Compartmentalization is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure.

Di LangHaibo NiRoman Y MedvedevFang LiuClaudia P Alvarez-BaronLeonid TyanDaniel G P TurnerAleah WardenStefano MorottiThomas A SchrauthChristian RickertCatherine ProenzaBaron ChandaTimothy J KampGail A RobertsonEleonora GrandiAlexey V Glukhov

Published in: bioRxiv : the preprint server for biology (2024)

SAN pacemaking is driven by complex protein interactions within a nanoscale caveolar pacemaker signalosome. Disruption of caveolae leads to SND, potentially representing a new dimension of SAN remodeling and providing a newly recognized target for therapy.

Keyphrases

heart failure
induced apoptosis
cell cycle arrest
lymph node
neoadjuvant chemotherapy
cell death
protein protein
vena cava
atrial fibrillation
amino acid
bone marrow
cardiac resynchronization therapy
acute heart failure
high resolution
cell proliferation
replacement therapy
high speed
inferior vena cava