Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma.

Prit Benny MalgulwarCarla DanussiSharvari DharmaiahWilliam E JohnsonArvind RaoJason T Huse

Published in: bioRxiv : the preprint server for biology (2023)

Our study demonstrates that SIRT2 inhibition promotes senescence in ATRX-deficient glioma model systems through global epigenomic remodeling, impacting key downstream transcriptional profiles.

Keyphrases

genome wide
dna damage
gene expression
transcription factor
endothelial cells
dna methylation
oxidative stress
stress induced
ischemia reperfusion injury
copy number